Amino acid and protein metabolism II

1. Amino acid and protein metabolism II

2.

3. Metabolism of glycine, serine and threonine

4. Metabolism of sulfur amino acids

Methionine + АТP
S- adenosylmethionine + РРi + Рi

5.

6. Metabolism of branched chain amino acids

Leu, Ile, Val
α-keto acids
acyl-CoA derivatives

7. Phenylalanin oxidation

8. Phenylketonuria

9. Tyrosine metabolism 

Tyrosine metabolism
Tyrosine
Dihydroxyphenyl
alanine (DOPA)

10. Albinism

11. Catecholamines

dopamine
noradrenaline
adrenaline

12. Thyroid Hormones

13. Tyrosine metabolism 

Tyrosine metabolism
Tyrosine
Homogentisic
acid
Fumarate
Acetoacetate

14. Homogentisuria

15. Tryptophan metabolism

16. Tryptophan metabolism

17. Iron

18. Transferrin

19. Ferritin

20. Heme

21.

22.

Hemoglobin
verdoglobin
(green pigment)
- iron
- globin
biliverdin (bile pigment)
Bilirubin

23.

Bilirubin
Bilirubin
diglucuronide

24. Jaundice

25.  Hemoglobin synthesis

Hemoglobin synthesis

26.  Hemoglobin synthesis

Hemoglobin synthesis
Succinyl-CoA + Glycine
5-Aminolevulinic acid
Protoporphyrin IX
Heme
Hemoglobin
+
Globin

27. Porphyria

28. NUCLEOPROTEIN AND NUCLEIC ACID METABOLISM

29. Purines catabolism

adenine hypoxanthine
guanine xanthine

30. Gout

31. Gout

32. Pyrimidines catabolism

33. Pyrimidine synthesis

CO2 + Glutamine + 2 ATP + H2O
H2N CO OPO3H2 + 2 ADP + H3PO4
CP + Asp …
orotydylic
acid
UMP + ATP UDP + ADP
UDP + ATP UTP + ADP

34. Purine synthesis

35. Purine synthesis

NAD
Inosine-5'-phosphate Xantozin-5'-phosphate
+ Asp
- fumarate
+ Gln
- Glu
+ GTP
- GDP, -Pi
+ ATP - AMP, -PPi
Adenosine-5'-phosphate
Guanosine-5'-phosphate

36.

dGDF + ATP dGTP + ADP