Lipid metabolism. Part 2

1. LIPID METABOLISM Part 2

2. Phospholipid

3. Self-organization of phospholipids

Selforganization of
phospholipids

4. Cleavage sites of phospholipases 

Cleavage sites of phospholipases

5. Phosphatidyl inositol calcium system

PiP2

6. Phospholipase A2 of bee venom

7. The synthesis of acetylcholine

The synthesis of acetylcholine
choline
Choline acetyltransferase
acetylcholine

8. Phospholipid synthesis

9. Violations of complex lipid metabolism

2
1
3
4
1 - Gaucher disease (glucocerebrosidase deficiency)
2 - Krabbe disease (galactocerebrosidase deficiency)
3 - Farber disease (ceramidase deficiency)
4 - Niemann-Pick disease (sphingomielinidase deficiency)

10. Polyunsaturated fatty acids

Polyunsaturated fatty acids
Linoleic acid (18:2;9,12)
Linolenic acid (18:3;9,12,15)
Arachidonic acid (20:4;5;8,11,14)

11. Eicosanoids synthesis

12.

13. Cholesterol

14. Cholesterol ester

15. Classification of steroids

С 27 (8)
С 21 (2)
С 24 (5)
С 18 (0)

16. Cholesterol synthesis

AcetylCoA acetyltransferase
2
Acetoacetyl-CoA

17.

18.

19.

mevalonate
ATP
farnesyl pyrophosphate (С15)
farnesyl pyrophosphate (С15)
NADPH+H+
squalene (C30)

20.

21. Regulation of cholesterol synthesis

22. Regulation of cholesterol synthesis

23. Cholesterol ester metabolism

Acylcholesterol + Н2О Fatty acid + Cholesterol

24.

25.

26. Bile acid synthesis 

Bile acid synthesis
Cholesterol
7- -hydroxylase
7- -hydroxy cholesterol
Reduction,
hydroxylation
3- ,7- - diol
Side chain
oxydation
3- ,7- - diol
Side chain
oxydation
Chenodeoxycholic acid
Cholic acid

27. Bile acid synthesis 

Bile acid synthesis
Cholesterol
Chenodeoxycholic acid
Cholic acid
Lythocholic acid
Deoxycholic acid

28. Stationary state

(Cholesterol endog + Cholesterol exog) =
= (Cholesterol excr + Bile acids excr)

29. Joseph L. Goldstein

30. Hyperlipidemia classification

31.

32. Cholesterol metabolism

33. Atherosclerosis

34.

35. Atherosclerotic plaque

36. Atherosclerotic plaque is surgically scraped from artery

37. Cholelithiasis

38. Xanthomatosis