Thesis proposal. AMF has shown to improve the sensitivity of molecular MSOT

1. Thesis proposal

Andrii Kravtsiv

2. Topic of the thesis

• AMF has shown to improve the sensitivity of molecular MSOT
imaging in a number of applications such as cell imaging
• However its applications is not robust in cases
– where the target occupies a large area in the image
– where the spectrum of the target agent is significantly corrupted by light
fluence
• This thesis will be devoted in studying the performance of AMF
under such challenging conditions and developing solutions for
mitigating such effects and ensuring global robust performance.

3. Preliminary Result 1: Study of the effects of target spectrum corruption due to light fluence

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Sensitivity limits of the different algorithmic approaches
AMF
AMF coloring
Sensitivity limit: Simulated    a (cm­1)
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Brain ICG
Brain ink
Kidney ICG
Kidney ink
 
• The effect of sensitiivty decrease
due to the corruption of the
target spectrum is studied
• While this effect is minimum
when agents with sharp
spectrum are considered (e.g.
ICG), spectral corruption can be
important when agents such as
ink are utilized.

4. Preliminary Result 2: Study of the effects of performance contamination due to targets occupying large areas

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The effect of sensitiivty decrease as a function of
the area of the molecular target is studied
Targets are implanted in gradually decreasing
areas and the sensitivity is calculated
We observe a significant degradation of
algorithmic performance as a function of the
target area.
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Area occupied by target
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5. Work in progress: Diagonal loading can enhance the detection performance when the target is occupying large areas

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prior background ­ mouse4
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contaminated background mouse3
diagonal loading, betha=10­8
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6.

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Performance of AMF filter with and without diagonal loading in covariance matrix