Trypanosoma Brucei

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Medical Academy named after S.I.
Georgievsky of Vernadsky CFU
TRYPANOSOMA
BRUCEI
PRESENTATION
BY PRAJAPAT
KALPESH 192B
SCIENTIFIC
ADVISOR –
SVETLANA
MAAM

Life Cycle of Trypanosoma brucei
1. When an infected tsetse fly bites a person (or animal), it injects a form
of the protozoa that can cause infection (called trypomastigotes) into the
skin. The protozoa move to the lymphatic system and bloodstream.
2. Inside the person, they change forms and travel to organs and tissues
throughout the body, including lymph and spinal fluid.
3. The protozoa multiply in the bloodstream and other body fluids.
4. They circulate in the bloodstream.
5. A fly ingests the protozoa when it bites an infected person.
6. Inside the fly, the protozoa change forms and multiply.
7–8. The protozoa travel to the fly's salivary glands, multiply, and change
into trypomastigotes—the form that is injected when the fly bites a person.

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Disease caused by trypanosoma brucei
African Trypanosomiasis, also known as
“sleeping sickness”, is caused by microscopic
parasites of the species Trypanosoma brucei. It
is transmitted by the tsetse fly (Glossina
species), which is found only in sub-Saharan
Africa.

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SYMTOMS
Pain areas: in the joints or
muscles
Sleep: insomnia or sleepiness
Weight: muscle loss and
weakness or weight loss
Also common: fever, headache,
itching, mental confusion,
personality change, problems
with coordination, skin rash, or
swollen lymph nodes

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TREATMENT
Only four drugs are registered for
the treatment of human
African trypanosomiasis: pentamidine,
suramin, melarsoprol and eflornithine. A fifth
drug, nifurtimox, is used in combination under
special authorizations.

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Can African sleeping sickness be
prevented?
Wear protective clothing, such as long-sleeved shirts and
pants. ...
Wear khaki, olive, or other neutral-colored clothing. ...
Use bed nets when sleeping.
Look inside vehicles for tsetse flies before getting into them.

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