When Medicines Are Powerless

1.

When medicines are
powerless: The Rise of
Superbugs
Авторы: Смолев С.А.,
Зенченко Е.В.

2.

The Silent Pandemic
1.27М
Deaths annually
According to the World Health Organization data for
2024, antimicrobial resistance is now a direct cause
nearly 5 million
Deaths where resistance played a secondary role

3.

The goal and tasks of our study
The goal of our study was to evaluate the key molecular mechanisms of
resistance and identify the behavioral factors among the population that
accelerate this process.
Describe the primary molecular "weapons" bacteria use
Conduct a social survey regarding antibiotic use
Compare our local findings with global trends
Formulate practical, life-saving recommendations.

4.

A Brief History of a Losing Race
1940s
Mass production saves
thousands in WWII; sepsis
mortality drops 10x.
1928
Fleming discovers
Penicillin
Today
Bacterial evolution is 5
times faster than science
1947
First resistant
Staphylococcus aureus
identified (Penicillinase).

5.

The Enemy’s Arsenal: 4 Molecular Mechanisms
Enzymes
The production of
beta-lactamases,
which physically
destroy the antibiotic
molecule.
Targets
Changing the shape
of proteins so that
the drug cannot
attach to the
bacterium.
Efflux
Biological pumps
pumping the
medicine out of the
cell.
Pores
Closing the
entrance channels
(porins) to prevent
penetration.

6.

The Human Factor: Social Survey Results
48%
48% - Stop treatment early once they feel better.
37% - Take antibiotics without a prescription (using "leftovers")
Stop treatment
15% - Strictly follow medical instructions.

7.

The Danger of "Feeling Better"
In the first two days, the antibiotic kills the weakest
bacteria. The temperature drops, the symptoms
disappear.
But this is not recovery.
By stopping the intake, you leave "partially stable"
individuals. You carry out artificial selection in your
own body, allowing the strongest to multiply.

8.

Why is This Happening?
Low Awareness
Mistakenly using antibiotics
for viral infections (flu/colds)
Availability
Easy access to drugs without
professional oversight.
Lack of Feedback
The consequences are delayed;
the "superbug" you create might
infect someone else years later.

9.

Practical Solutions & Recommendations
For the healthcare system
1. The introduction of digital prescriptions to track the reception history.
2. Monitoring of excessive drug consumption at the state level.
For the public
1. Prohibition on "leftovers": never use or share medicines from old stocks.
2. The "alarm clock rule": setting reminders for taking antibiotics at a strictly fixed time
(crucial for the destruction of all bacteria in the cycle).
Information campaign
1. Including the basics of proper antibiotic use in the school curriculum.
2. Active education on social media.

10.

Conclusion
Our research proves that 48% of the population is
accidentally helping bacteria evolve.
Thank you for your attention. I am now open for questions.