Structure & functions of biological membranes

1.

STRUCTURE &
FUNCTIONS OF
BIOLOGICAL MEMBRANES

2.

STUDY OF BIOLOGICAL MEMBRANES
х54000
PHOSPHOLIPID

3.

Lipid monolayer
Hydrophilic group
Hydrophobic group
Hydrophilic group
Lipid bilayer
Proteins
Proteins
Sandwich model

4.

LIQUID MOSAIC MODEL OF BIO MEMBRANE
Singer & Nikolson, 1972
Peripheral protein
Phospholipid bilayer
Carbohydrate
Cholesterol
Липид
Receptor protein
Transport protein
Ferment protein
Cytoskeleton

5.

MODEL MEMBRANE. LIPOSOME

6.

SELFCONSTRUCTION OF PHOSPHOLIPIDS

7.

BIMOLECULAR LIPID MEMBRANES

8.

PHOSPHOLIPID MOLECULES MOTION
THERMAL EFFECT
rotation
Lateral
diffusion
Diffusion
T=10-7-10-8s
Flip-flop
5,8 nм
4,7nм
3,9 nм

9.

Flip-flop

10.

BIOMEMBRANE FUNCTIONS

11.

BIOMEMBRANE FUNCTIONS

12.

BILIPID LAYER PENETRABILITY
SMALL
MOLECULES
GASES
HYDROPHOBIC
MOLECULES
BIG
MPLECULES
IONS

13.

MEMBRANE PROTEINS
KINDS OF PROTEINS
INTEGRAL
PERIPHERAL

14.

MEMBRANE PROTEINS

15.

MEMBRANE PROTEINS FUNCTIONS
TRANSPORT
a) Passive
transport;
b) Active
transport
й

16.

TRANSPORT FUNCTION

17.

MEMBRANE TRANSPORT
FUNCTION
PASSIVE TRANSPORT
ACTIVE TRANSPORT

18.

PASSIVE TRANSPORT
Filtration
Osmosis
Simple
diffusion
Through
lipid
Through
bilayer lipid
bilayer
pores
Through
protein
pores
dm
dc
D
S
dt
dx
Facilitated
diffusion
Nonfixed
carrier
Fixed carrier

19.

ACTIVE TRANSPORT
ION PUMPS
SECONDARY ION
TRANSPORT
ENDOCYTOSIS
EXOCYTOSIS

20.

ION PUMPS
K+-Na+ pump
Ca2+ pump
H+ or proton pump

21.

Secondaryactive transport
uniport
simport
antiport

22.

ENDO- & EXOCYTOSIS
ENDOCYTOSIS KINDS
FAGOCYTOSIS
PINOCYTOSIS

23.

ENDOCYTOSIS

24.

TRANSPORT FUNCTION