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Regulation of metabolism
1. Regulation of metabolism
2. Metabolism
3. Hormones
4.
5. Insuline
6. The formation of active insulin
7. Insulin receptor
8. Insulin
The signal for Targetsecretion
organs
Increasing
Liver
the
concentration
of glucose
Muscles
in the blood
Changes in metabolism
in target cells
1. The acceleration of glycogen synthesis
2. The acceleration of protein synthesis
3. Inhibition of gluconeogenesis
1. The acceleration of glycogen synthesis
2. The acceleration of protein synthesis
3. The acceleration of glucose transport into
the cell
Adipose
tissue
1. The acceleration of fat synthesis from
glucose
2. The acceleration of glucose transport into
the cell
9. Glucagon
10. Glucagon receptor
11. Glucagon
Thesignal
Target
Changes
Сигнал для секреции
Органы-мишени Изменения
for secretion
organs
in metabolism
метаболизма в in
клетках-мишенях
target
cells
Понижение
Печень
1. Ускорение
Lowering
1. The распада
acceleration
концентрации Liver
blood
glucose
of glycogen
breakdown
глюкозы
в крови
гликогена
Ускорение
levels
2. The 2.
acceleration
глюконеогенеза
of gluconeogenesis
Жировая ткань Ускорение
Adipose The acceleration
липолиза
tissue
of lipolysis
12. Adrenaline
13. Adrenaline recertors
14. Adrenaline
The signal forsecretion
Signal of CNS
Target organs
Liver
Muscles
Adipose tissue
Changes
in metabolism in
target cells
The acceleration
of glycogen
breakdown
The acceleration
of glycogen
breakdown
The acceleration
of lipolysis
15. Cortisol
16. The regulation of cortisol synthesis
17. Cortisol receptor
18. Cortisol
The signal forTarget
Changes in metabolism in
organs
target cells
secretion
1. Acceleration
The
Liver
of gluconeogenesis
concentration
of glucose in the
2. Induction of synthesis of
the enzymes of
blood mediated
gluconeogenesis and amino
by corticotropin
acids catabolism
Muscles 1. The acceleration of the
amino acids catabolism
2. Reducing the rate of
the amino acids transport
19. Changes in metabolism in starvation
20. Changes in metabolism in starvation
21. The main manifestations of diabetes
Decreased synthesis and depositionof glycogen and fat
Hyperglycemia
Hyperlipoproteinemia
Ketonemia
Azotemia and azoturia
Polyuria and polydipsia
22. Protein glycosylation
23.
24. Cushing’s disease
25. REGULATION OF PHOSPHORUS AND CALCIUM METABOLISM
26. Calcium metabolism
1000 mg200 mg
200 mg
Intestine
Blood
Kidneys
200
mg
800 mg
Sceleton
200 mg
27. Phosphorus metabolism
1000 mg800 mg
800 mg
Intestine
Blood
Kidneys
200mg
Sceleton
800 mg
28. Parathyroid hormone
29. Vitamin D3
30. Vitamin D3 activation
Cholesterol(skin)
Vitamin D
(cholecalciferol)
25-hydroxycholecalciferol
(liver)
1,25-dihydroxycholecalciferol
(kidneys)
UV-rays (300-310 nm)
Food
PTH
Са2+
31.
32. Rickets
33.
34. Calcitonin
35. Calcitonin
36. Hormonal regulation of phosphates transport
Parathyroidhormone
Insulin
_
+
+
Absorption
in the
intestine
+
The bone
resorption
+
1,25-(ОН)2-D3
+
+
Reabsorption
in the tubules
_
Glucagon
+
Growth
hormone
37. The influence of biologically active substances on the phosphates excretion
SubstanseGlucagon
Glucocorticoids
Thyroxine
Growth hormone
Insulin
Serotonin
Catecholamines
Phosphates excretion
38. WATER and SaLT metabolism RENAL BIOCHEMISTRY
39. Water functions
40. Urinalysis
41.
42.
HematuriaHemoglobinuria
43.
Urinary stones44. Vasopressin
45.
46.
47.
48. Atrial natriuretic peptide (ANP)
49. Kallikrein-kinin system
50.
angiotensinogenrenin
prorenin
kininogen
angiotensin I
kallikrein
activation
carboxycathepsin
angiotensin II
(rises BP)
deactivation
kinins
(bradykinin,
kallidin)
(lower BP)
ANGIOTENSINASE
INACTIVE
PEPTIDES
INACTIVE
PEPTIDES