Pathogenesis and treatment of primary biliary cirrhosis

1.

Pathogenesis and
treatment of primary
biliary cirrhosis
Name: Eduard Miasnikov
Group: L1-226-2

2.

AIM:
Tasks:
1. What is PBC?
2. Incidence and prevalence

3.

What is PBC?
Primary biliary cirrhosis (PBC) is an
idiopathic chronic autoimmune liver
disease that primarily affects
women. It is believed that the
aetiology for PBC is a combination
between environmental triggers in
genetically vulnerable persons.

4.

The diagnosis for PBC is made when two of the three criteria are
fulfilled and they are:
(1) biochemical evidence of cholestatic liver disease for at least 6 month's duration;
(2) anti-mitochondrial antibody (AMA) positivity;
(3) histologic features of PBC on liver biopsy;

5.

Incidence and prevalence
We identified 5,350 adults (15 years of age and older) with a PBC
diagnosis and 50,145 reference individuals. The PBC incidence rate
was around 2.6 per 100,000 person-years with some variability that
mainly can be explained by the start of different registers (a likely
overestimation 1987–1988, as well as 2001–2002), change in ICDcoding system and changes in care of patients. There was a steady
increase in the registered prevalence of PBC from 5.0 (1987) to 34.6
(2014) per 100,000 inhabitants, also with some variability due to the
difference in available registers. From 2004 to 2014 the data is
however likely to cover the full prevalent cohort of PBC diagnosed
patients, where the incidence is very stable, and the increase in
prevalence is close to linear.

6.

Incidence rates (per 100,000 person-years, red) and prevalence rates
(per 100,000 person-years, blue) for PBC in Sweden from 1987 to 2015.

7.

The median age of the whole study population was 64 years at
diagnosis (range 15–94), and 9 out of 10 patients were born in
Sweden. The female:male ratio in the whole study population was
4.0:1, with a higher proportion of women (5.4:1, 84.5%) in the
outpatient population 2001–2014.

8.

Data about authors, locations and publication dates of articles (NBCI)
1. Division of Gastroenterology and Hepatology, Mayo Clinic College
of Medicine, USA; 2010.
2. Collaborators: Inova Fairfax Hospital, Zucker School of Medicine at
Hofstra, Bon Secours Liver Institute of Virginia, Stanford University
Medical Center, Stanford University School of Medicine, Swedish
Medical Center, New York; 2019 Jan.

9.

Addresses of articles from the site of NCBI
https://pubmed.ncbi.nlm.nih.gov/20955967/
https://pubmed.ncbi.nlm.nih.gov/30429590/