SpecWhite®SAP

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SpecWhite®SAP
Sodium Ascorbyl Phosphate
www.specchemind.com

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Index
1.Introduction
2.Characteristic
3.Effect
4.Application

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1.Introduction
Description:
Sodium Ascorbyl Phosphate(SAP) is a stable vitamin C, it is an
active ingredient for sophisticated cosmetic skin-care products.
It protects skin ,promotes its development and improves its
appearance.
It is cleaved enzymatically in the skin to release active vitamin C.

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1.Introduction
Product No:
110023
INCI Name:
Sodium Ascorbyl Phosphate
Synonym:
L-Ascorbic acid 2-phosphate trisodium salt
Molecular Formula:
C6H609Na3P
Molecular Weight:
322.05g/mol
CAS No.:
66170-10-3
EC / List no.:
613-904-0
Structural formula

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2.Characteristic
1.Stable vitamin C
2.White or almost white powder
3.Similar effect with vitamin C

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3.Effect
1.Whitening, lightens hyperpigmentation
2. Antioxidant properties
3.Promotes collagen synthesis
4.Anti-inflammatory, anti-acne

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3.1Whitening, Lightens hyperpigmentation
SAP is converted to vitamin C and enters the cells, it can
significantly lighten existing black melanin by a reduction
reaction.

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3.2Antioxidant
Suppression of lipid
peroxidation by
topically applied SAP
compared with an
untreated area of
skin ,in 20 test persons.
The result show that 1%SAP formulation can reduce UV-induced lipid peroxidation.

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3.3Collagen Synthesis
Recent studies with cell cultures added with L-ascorbic acid-2phosphate have shown that vitamin C is one of the cell growth
factors that activate collagen synthesis.

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3.4 Anti-inflammatory
SAP has a strong
antimicrobial activity on
P. acnes, which is the
major bacterium involved
in developing acne
vulgaris.
Representative subject from the group treated with 5% SAP. Patient has apparent inflammatory and
non inflammatory lesions of acne vulgaris before treatment(left picture). The beginning of the study
(time point zero) is shown on the left panel as picture of the face and a magnification of the cheek,
whereas the right panel shows the promising result after a 12-week application twice a day.

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4.Application
Application:
SAP has already been used in cosmetics:anti-wrinkle products,
whitening products, protection formulations, body lotion, night
cream and day cream.
Dosage:
1. 0.2-2% in daily sin care products.
2. 0.2 - 1 % in sun care products.
3. >3% in lightening products.

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Usage
Solubility :It is possible to prepare solution of up to 64% in water(very soluble in
water),13.2% in glycerol and 1.6% in propylene glycol ,it is in soluble in ethanol,
isopropyl myristate, cetostearyl octanoate, caprylic/capric triglyceride and C1215 alkyl benoate.
Temperature:in the production of cosmetic care products,it is recomemended to
add SAP to formulations at a low temperature(<40℃).it can be exposed to higher
temperatures up to 80℃,but only for a short time, finished formulation should be
stored at below 25 degree.
pH use level :this product is most stable above PH 6.5.it is recomemed to use a
buffer system and add a cheating agent.
Compatibility:Sodium ascorbyl phosphate is compatible with most cosmetic
ingredients. however ,it is incompatible with heavy metals, low
pH,heat.moisture.
SAP show synergistic action of vitamin E,vitamin E acetate and Vitamin C for
antioxidant activity.

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Stabilty
SAP is far more stable than ascorbic acid in water.

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Stability of sodium ascorbyl phosphate in microemulsions
SAP was stable in both microemulsions with no significant influence of the location in the
carrier system ,After 2 months, more than 95% of non-degraded compound remained in both
microemulsions (Fig. 2). According to literature data and producer specification, ascorbyl
phosphate salts are among the most stable ascorbic acid derivatives. High stability is the
result of its chemical structure.
Reference:Sodium ascorbyl phosphate in topical microemulsions.

15.

Paula's Choice Resist Anti-Aging
Clear Skin Hydrator
Dr Jart+ V7
Vitamin Solution
Vitamin C
Sodium Ascorbyl
Phosphate –
Helps to protects
the skin from UV
damage, helps
maintain skin
resilience with
anti-oxidizing
agents

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Dr. Dennis Gross
Skincare HydraPure Vitamin C
Brightening Serum
DDF Erase Eye Gel

17.

Formulation Example 1 Lotion with 3% Sodium Ascorbyl Phoshate
Phase
A
INCI Name
Cremophor® WO 7
Quantity (%)
6.00 %
A
A
A
Isopropyl Myristate
Luvitol® EHO
TeCero Wax 1030 K
5.00 %
5.00 %
2.00 %
A
A
A
A
Bees Wax 3044 PH
Cetiol SB 45
Jojoba Oil
Paraffin Oil
0.50%
0.50 %
2.00 %
10.00 %
B
1,2-Propylene Glycol Care 5.00 %
B
B
B
Preservative
Water dem.
Sodium Ascorbyl
C
Sodium Ascorbyl Phosphate 3.00
D
Perfume
q.s.
51.00
3.00 %
Procedure:
Heat phases A and B
separately to about 85°C.
Stir phase B into phase A
whilst homogenizing and
continue homogenizing for
a while.
Cool to about 40°C, add
phases C and D and
homogenize again.
q.s.
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Formulation Example 2 Cleaner
Phase INCI Name
A
Quantity (%)
PEG-40 Hydrogenated Castor Oil q.s.
A
Propylene Glycol
3.00
A
A
Bisabolol
Alcohol
0.10
15.00
A
Witch Hazel (Hamamelis
Virginiana) Distillate
2.00
A
Sodium Ascorbyl Phosphate
1.00
A
A
Aqua
Fragrance
78.90
q.s.
Procedure :
Weigh out the components and
dissolve them clearly. Adjust the
pH value to 5-6
Cleansing lotion containing Sodium
Ascorbyl Phosphate (a stable vitamin C
derivative).
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19.

Technical Data sheet
Item
Standard
Appearance
White or almost white powder
Clarity of solution
3% solution is clear, And is not more
intense in turbidity than No.3 turbidity
Standard solution.
Identification
Positive
Assay
≥ 98.0%
PH
8.0-10.0
Loss on drying
≤10%
Residue on Ignition
≤ 0.1%
Heavy metal
≤10ppm
Annotate: the data in the sheet is reference, practice data should be according to COA sheet.
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Package :
- 1kg/Aluminum foil bag
- 25kg/carton
Storage
Protect from light and keep in cool and dry place.
Shelf life:
2years.
The above information is provided by the Spec-Chem Industry Co., Ltd,the main purpose is to facilitate the use of
cosmetics product development professional and technical personnel.The reliability of the information the user should be
based on their knowledge and ability to make judgments, and can be modified accordingly within a reasonable supplement
to this all the consequences, Spec-Chem Industry Co., Ltd. does not assume any responsibility

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Reference
Geesin JC, Gordon JS, Berg RA. Regulation of collagen synthesis in human dermal fibroblasts by the sodium and
magnesium salts of ascorbyl-2-phosphate.[J]Skin Pharmacol. 1993;6(1):65-71.
Hata R1, Senoo H.L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation
of a three-dimensional tissuelike substance by skin fibroblasts[J].Cell Physiol. 1989 Jan;138(1):8-16.
Ono M, Aratani Y, Kitagawa I, Kitagawa Y.Ascorbic acid phosphate stimulates type IV collagen synthesis and
accelerates adipose conversion of 3T3-L1 cells[J]Exp Cell Res. 1990 Apr;187(2):309-14.
Takamizawa S, Maehata Y, Imai K, Senoo H, Sato S, Hata R.Effects of ascorbic acid and ascorbic acid 2phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like
cells[J].Cell Biol Int. 2004;28(4):255-65.
Ikeno J, Nishikawa T. Clinical evaluation of topical sodium L-ascorbyl-2-phosphate lotion (5%W/V) in patients
with acne. Presented at the Society for Investigative Dermatology 3rd Annual Meeting; 2002 May15–18; Los
Angeles, CA.
Ikeno H, Ohmori K. Clinical study of safety and efficacy of 5% sodium L-ascorbyl-2-phosphate lotion to treat acne
scars after glycolic acid peels. Cosmet Dermatol 2003;1:29–33.
J. Klock, H. Ikeno, K. Ohmori, T. Nishikawa.Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the
prevention and treatment of acne vulgaris[J]International Journal of Cosmetic Science, 2005, 27, 171–176.

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hesitation
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