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Аутофагия, как новая мишень в лекарственной терапии метастатической меланомы
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Аутофагия, как новая мишень в лекарственной терапииметастатической меланомы
Выполнил:
Студент 5 курса 21 группы
лечебного факультета
Жуликов Ярослав
Научный руководитель:
к.м.н., ассистент кафедры онкологии
ПМГМУ им. И.М. Сеченова
Синельников Игорь Евгеньевич
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ИсторияChristian René de Duve
1974- нобелевская премия за открытие
лизосом
Yoshinori Ohsumi
2016- роль аутофагии в процессах
старения, похудения, канцерогенеза
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*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi KAutophagy in malignant transformation and cancer progression. The EMBO Journal Vol 34 | No 7 | 2015
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* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian.Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies.
Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388
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* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian. Autophagy, autophagy-associated adaptive immune responses and its role inhematologic malignancies. Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388
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*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi KAutophagy in malignant transformation and cancer progression. The EMBO Journal Vol 34 | No 7 | 2015
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*Lorenzo Galluzzi, Federico Pietrocola, José Manuel Bravo-San Pedro, Ravi K9.
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*María García-Fernández, Panagiotis Karras, Agnieszka Checinska, Estela Cañón, Guadalupe T. Calvo. Metastatic risk and resistance to BRAF inhibitors inmelanoma defined by selective allelic loss of ATG5. AUTOPHAGY 2016, VOL. 0, NO. 0, 1–15. http://dx.doi.org/10.1080/15548627.2016.1199301
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*X Sui, R Chen, Z Wang, Z Huang. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.Cell Death and Disease (2013) 4, e838; doi:10.1038/cddis.2013.350
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* M Corazzari, F Rapino, F Ciccosanti, P Giglio. Oncogenic BRAF induces chronic ER stress conditionresulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death and Differentiation (2014), 1–13
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*Anna Ferrettaa, Immacolata Maidaa, Stefania Guidab, Amalia Azzaritic. New insight into the role of metabolic reprogramming inmelanoma cells harboring BRAF mutations.
BBA - Molecular Cell Research (2016), doi: 10.1016/j.bbamcr.2016.08.007
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* M Corazzari, F Rapino, F Ciccosanti, P Giglio. Oncogenic BRAF induces chronic ER stress conditionresulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Cell Death and Differentiation (2014), 1–13
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*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9
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Ингибирование аутофагии сенсибилизируетклетки к действию вемурафениба
*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9
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*S Sanduja, Y Feng, RA Mathis, ES Sokol, F Reinhardt, R Halaban.AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene (2016), 1–9
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*María García-Fernández, Panagiotis Karras, Agnieszka Checinska, Estela Cañón, Guadalupe T. Calvo. Metastatic risk and resistance to BRAF inhibitors inmelanoma defined by selective allelic loss of ATG5. AUTOPHAGY 2016, VOL. 0, NO. 0, 1–15. http://dx.doi.org/10.1080/15548627.2016.1199301
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*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen, Sumedh S. Shah. BRAF inhibitor resistance enhances vulnerability to argininedeprivation in melanoma. Oncotarget 2016, Vol. 7, No. 14
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*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen,Sumedh S. Shah. BRAF inhibitor resistance
enhances vulnerability to arginine deprivation in
melanoma. Oncotarget 2016, Vol. 7, No. 14
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*Ying-Ying Li, Chunjing Wu, Shu-Mei Chen, Sumedh S. Shah. BRAF inhibitor resistance enhances vulnerability to argininedeprivation in melanoma. Oncotarget 2016, Vol. 7, No. 14
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* Liangshun You, Shenhe Jin, Li Zhu, Wenbin Qian.Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies.
Oncotarget, 2017, Vol. 8, (No. 7), pp: 12374-12388
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Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Sandra Demaria, Silvia Chiara Formenti and Guido KroemerActivating autophagy to potentiate immunogenic chemotherapy and radiation therapy.
NATURE REVIEWS | CLINICAL ONCOLOGY 2016