Pivastalo. Действие

1.

2.

Different
iation in
Pharmacol
ogical
Action
Pleiotro
Prevention of
pic
major
CV events
effect
Lower
Drop
Patient
adherence
out
rate

3.

Pivastalo
®
A distinctive lipid lowering drug
The Lowest Statin Dose *1
Providing inhibition of cholesterol synthesis and
increased lipoprotein lipase expression
*2
The Highest Bioavailability
Pivastalo has a higher bioavailability
(60%-80%) than any other statin
Minimal drug–drug and drug–food interactions
*2
Metabolism by CYP2C9 and not metabolized by CYP3A4

4.

Pivastalo
Effective lipid lowering dru
Effective, first-line therapy that offers an alternative, simple treatment regimen in the
long-term care of primary hypercholesterolemia and combined dyslipidemia.
Dragos Budinski, Pitavastatin compared with atorvastatin in primary hypercholesterolemia or combined dyslipidemia Clin. Lipidol. (2009)

5.

The
Pivastalo
Neutral effect on
cumulative
incidence
of ( New
Glycemic
Control
Onset of
Diabetes Mellitus )NODM
was significantly lower in Pivastalo group
Compared with the atorvastatin and rosuvastatin
groups
John Jp Kastelein, Pitavastatin: an overview of the LIVES study Clin. Lipidol. (2012)
JahYeonChoi, Effect of Pitavastatin Compared with Atorvastatin and Rosuvastatinon
New-Onset Diabetes Mellitus in Patients With Acute Myocardial Infarction, Am J Cardiol 2018

6.

Pivastalo
Offers Cardiomediated
High-Density
lipoprotein
Protective
Profile
“The
(HDL)
elevation with
slow the formation
of atherosclerotic plaques and reduce the
residual Cardiovascular risk“
John Jp Kastelein, Pitavastatin: an overview of the LIVES study Clin. Lipidol. (2012)
Luis Masana, Pitavastatin in cardio metabolic disease: therapeutic profile
Masana Cardiovascular Diabetology 2013

7.

Pivastalo
Lower Drop Rate
“
has the lowest incidence of Adverse
Reports“
In controlled clinical studies and the open-label extension, the discontinuation rates due to adverse events were 3.9%, 3.3%
and 3.7% for the 1 mg, 2 mg, and 4 mg doses of Pitavastatin respectively.