1. Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice
Anton Krotov, Skoltech Institute Selection Event, Moscow, 2016
From R&D Systems website www.rndsystems.com
Hepatocellular carcinoma
from Cleveland clinic website - http://www.clevelandclinicmeded.com/
Comoglio et al., Nature Reviews 2008
Intravenous injection
Mouse with spontaneous
MET/∆N-90-β-catenin-driven HCC
Lipidoid-based nanoparticles
with siRNA against Itgb1
6. Hepatocyte-specific Itgb1 knockdown in mouse liver
Bogorad et al., Nature Communication 2014
7. The effect of integrin knockdown in liver in vivo
Bogorad et al., Nature Communication 2014
8. The effect of integrin knockdown in liver in vitro
Bogorad et al., Nature Communication 2014
9. The long-term downregulation of integrins in vivo
Bogorad et al., Nature Communication 2014
10. The effects of Itgb1 downregulation on mouse and human HCC cells
Bogorad et al., Nature Communication 2014
11. The effects of Itgb1 downregulation on spontaneous HCC
Bogorad et al., Nature Communication 2014
12. The effects of Itgb1 downregulation on spontaneous HCC
Bogorad et al., Nature Communication 2014
13. The effects of Itgb1 knockdown on expression and signalling of MET and β-catenin oncogenes
Bogorad et al., Nature Communication 2014
14. The effects of si-Itgb1 on MET protein maturation
Bogorad et al., Nature Communication 2014
15. The Itgb1 knockdown affects pathway activation
Bogorad et al., Nature Communication 2014
Lam et al., Molecular Therapy Nucleic Acids 2015