Hyamax CE Plus Series Product Introduction

1.

Plus Series

2.

What Difference Plus Series
New
3D High Efficiency Crosslink Technology
High Viscoelasticity
√ Volumzing
√ Sculpting
√ Correcting
√ Boosting
More
LESS
High Concentration:
20mg/ml
Less BDDE
Less inflammation risk
Long Lasting
√ Up tp 18 months
Less SwF
Less recover duration
Professional use only

3.

High Quality Raw Materials
Approved raw material
Hyamax is manufactured using safe and qualified
hyaluronic acid approved us FDA and European
Directorate for the quality of medicines (EDQM)
Safe material
Safe material with less than 10 ppm of
heavy metal (standards for US FDA and
EDQM is 20 ppm)
PH. Eur
Hyamax
Residual protein
Maximum 0.3% or 0.1 %
Maximum 0.1%
Endotoxin
<0.5 or 0.05 IU/mg
<0.05 IU/mg
Professional use only

4.

Hyamax 3D High Efficiency Cross-link Technology
Hyamax 3D High Efficiency Cross- link Technology = An excellent Product
Secondary
Interpenetrating
Cross-inking
Gradient
Layered
Cross-linking
-OH Group
-COOH
Group
-NHAc Group
HA
pH
Temperature
Catalyst
Low Temp
Phosphate
Buffer
Interpenetrating
High Temp
Microclustrs
*Avoid ineffective Dangling crosslinker
Data from: Hyamed laboratories Geneva
Gradient Structure
*Avoid BDDE excessive used at one time
3D Dense Structure
*Densify & Stabilize

5.

MultiStep Pure-Tech Technology
Hyamax using the MultiStep puretech technology, eliminating the
residual BDDE effectively
BDDE Reaction
No BDDE Reaction
MultiStep Pure-tech
Technology
Rehydration
Precipitation
Laundering
Gas Chromatograph
Gas Chromatograph
“NO” residues and LESS adverse reactions
Data from: Hyamed laboratories Geneva
Professional use only

6.

Temperature
Less Swelling
Hyamax utilizes a rapid temperature rise
and fall sterilization process to ensure
product sterility while minimizing
damage to the HA structure and
effectiveness,
130
120
110
100
90
80
70
60
0
It reduces the water absorption and
swelling rate of free HA, preventing
excessive swelling after injection.
5
Data from: Hyamed laboratories Geneva
10
15
20
25
Timeline
Professional use only

7.

Patient Safety Is A Priority
Performance Test
Item
Standard
Average Result
Form
No impurities, Transparent and
colorless gel
Pass
Concentration of HA
18.5-22.5 mg/mL
20.3 mg/mL
pH
6.8-7.5
7.1
Osmolality
270~350mOsmol/kg
288.3 mmol/kg
BDDE Residue
≤2ppm
Not Detected (≤0.3ppm)
Endotoxin
<0.5EU/mg
<0.04EU/mg
Sterility
Sterility
Sterility
Endotoxin and BDDE
levels are below the
standard
Data from: Hyamed laboratories Geneva
Professional use only

8.

Product Line
Product Name
PLUS FINE
PLUS DEEP
PLUS EXTRA DEEP
PLUS LIPS
HA Concentration
20 mg/ mL
20 mg/ mL
20 mg/ mL
20 mg/ mL
Particle Size
Average 100-300μm
Average 200-400μm
60% 400-1000μm (Complex)
Average 500μm
Needle Size
30G
27G
27G
27G
Package
2*1.0ml
2*1.0ml
2*1.0ml
2*1.0ml
Estimated Duration
6-9 months
6-12 months
6-12 months
6-9 months
CrD
about 1%
about 1%
about 1%
about 1%
Indication
Hyamax® Plus Fine is indicated to be
used for superficial dermis injection
for correction of fine lines and
wrinkles or
facial defects.
Data from: Hyamed laboratories Geneva
Hyamax® Plus Deep is indicated to be
used for a facial tissue augmentation Hyamax® Plus Extra Deep is used for
Hyamax® Plus Lips is intended to
for mid to deep dermal implantation
filling very deep lines: Laugh lines,
be used for lip defects or volume
for the correction of moderate to
oral commissures, nose bridge, chin,
enhancement.
severe facial wrinkles and
cheek, facial lines
folds.
Professional use only

9.

Product Line
Extractible
Product
Volume
(ml)
Ejection Force
Osmolarity
(N)
(mosm/L)
Average Particle
Size
pH
G' at 1 Hz
(Pa)
Zero-shear
Viscosity
(Pa.s)
Hyamax® Plus Lips
1.1 ± 0.0
10 ± 0
303
500um
7,0
674
8590
Hyamax® Plus Deep
1.1 ± 0.0
11 ± 0
304
700um
7,1
663
8302
Hyamax® Plus Extra Deep
1.1 ± 0.0
16 ± 0
301
60% 400-1000um
(Complex)
7,1
758
9826
Hyamax® Plus Fine
1.1 ± 0.0
22 ± 0
302
250um
7,1
625
7318
Data from: Hyamed laboratories Geneva
Professional use only

10.

Injection Layer
Epidermis
Dermis
Subcutaneous
tissue
Muscle
Plus Lips
Plus Fine
Plus Deep
Plus Extra Deep
Bone
2009 Cosmetic Dermatology PRINCIPLES AND PRACTICE II
Professional use only

11.

Hyamax Solution
Hyamax® PLUS Series
Explore the science behind our CE-certified products, designed
for safe, effective, and long-lasting aesthetic results.
Plus Fine
Ideal filler Reduce lines and wrinkles
• Forehead Lines
Plus Extra Deep
Ideal filler for Deep filling of the face
for Shaping
• Crow’s Feet
• Brow Bow
• Tear Troughs
• Nose Bridge
• Glabella Lines/Volume
• Nose Tip
• Perioral Lines
• Nose base
• Chin
Plus Deep
Plus Lips
Ideal filler moderate for mid to deep dermal
to severe facial wrinkles and folds
Forehead Volume
Temporal Zone
Cheek
Marionette Lines
Ideal filler for lips and Earlobe
Less swelling factor
Professional use only

12.

Common Injection Sites and Recommended Dosage
Injection Site
Injection Dose
Injection Site
Injection Dose
Forehead Lines/Glabella Lines
0.1ml/Cm
Nose Bridge Nasion
1-2ml
Forehead Volume
2-6ml
Nose Tip
0.1-0.3ml
Tear Troughs
0.2-0.5ml/Side
Orbital Region
1-2ml/side
Glabella Volume
1-2ml
Cheek
1-3ml/side
Marionette Lines
0.5ml/Side
Nasolabial Fold
1-2ml/side
Earlobe
0.2-0.5ml/Side
Temporal Zone
1-3ml/side
Lip
0.2-0.5ml/Side
Geison Brow Bow
0.5-1ml/side
Professional use only

13.

Before & After
Plus Lips for Lips Volume Creation
Plus Deep for Nasolabial Lines
Plus Extra Deep for Nose Reshaping
Plus Fine for Tear Troughs
Data from: Hyamed laboratories Geneva
Professional use only

14.

Customer Satisfactory
GAIS Improvement Evaluation (%)
Lemperle Wrinkle Scale (LWS)
P<0.05 vs D0
n=75
4
3.5
3
2.5
93.33%
Improvement
2
1.5
1
0.9333
0.5
0
D0
4 Weeks
8 Weeks
16 Weeks
24 Weeks
LWS Evaluation on 75 female patients treated Nasolabial Folds
by using Plus Deep.
Average age 48 yrs (Range 35-70 yrs)
measure at 4 weeks and 48 weeks after 1st treatment
Yan Wu et al, Arch Dermatol Res (2016) Apr;308(3):145-51.
Data from: Hyamed laboratories Geneva
48 Weeks
* GAIS Evaluation on 75 patients treated Nasolabial Folds by using Plus Deep
Average age 48 yrs (Range 35-70 yrs)
measure at 4 weeks and 48 weeks after 1st treatment
Aesthetic improvements,
assessed using the GAIS,
were observed in 100% of
both investigators and
subjects, with 93.33%
believing the improvements
lasted up to 6 months (48
weeks) after the final
injection.

15.

Customer Satisfactory
2nd Treatment Continue
Recommend to others
95%
95
Yan Wu et al, Arch Dermatol Res (2016) Apr;308(3):145-51.
Data from: Hyamed laboratories Geneva
Questionnaire Evaluation on 75 patients treated Nasolabial Folds by
using Plus Deep
Average age 48 yrs (Range 35-70 yrs)
measure at 4 weeks and 48 weeks after 1st treatment
95.8%
95.8

16.

M E D I C A L A EST H E T I C CO M PA N Y F RO M
SW I T Z E R L A N D
Fo u n d e d i n
HYAMED
Offering a one-stop solution for anti-aging,
contouring, and rejuvenation.
Serving
2011 w i t h 10+ ye a rs o f ex p e r i e n c e
70+ co u n t r i e s a n d re g i o n s
18% a n n u a l r ev e n u e i nv e ste d i n R & D
33+ p ate nt c e r ti fi c ate s

17.

ONE CENTER TWO FACTORIES
Laboratories in Geneva Switzerland
Factory in Chambéry France
Factory in ZhuHai China

18.

WORLD - CLASS EQUIPMENTS
Germany
Italy
Groninger pre-filled
syringe filling machines
Air steam mixed gas
sterilization cabinet
France
Planetary mixer
Italy
Dry heat
sterilization cabinets

19.

THANK YOU
Laboratories Hyamed S.A.