Mechanism of action of supatret 0.04% gel - ogm

1.

MECHANISM OF ACTION OF SUPATRET 0.04% GEL - OGM
MECHANISM OF ACTION OF SUPATRET 0.04% GEL
20GM:
Tretinoin is a trans-retinoic
shape of vitimin A. It stimulates mitosis and turnover of
acid
follicular
epithelial cellsand reduce their cohesiveness.
helps extrusion of present comedones and
This
forestallsformationof new comedone. It alsoexhibits thinningeffect on the stratum corneum. In
acute promyelocytic leukaemia, it
cell differentiationand decreasesproliferations.
induces
Absorption: Well absorbed from the GIT,top plasma concentrations after 1-2 hrs
(oral).
Oral bioavilability: 50%. Distribution:
bound to plasma proteins. Metabolism:
by way
Highly
Hepatic
of cytochrome P450 isoenzyme;transformed to isotretinoin, 4-oxo-trans-retinoic acid d
an
4-oxo-cis-retinoic acid. Excretion: Urine and faeces; 0.5-2 hrs
removal half-life).
(terminal
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SPECIAL PRECAUTIONS FOR SUPATRET 0.04% GEL
20GM:

2.

Topical: keep away fromconcomitant topical applications, esp keratolytic agents.
publicity to
Avoid
sunlight, UV mild and climate extremes (e.G. Cold).
far from eyes, mouth, angles of nose,
Keep
mucous membranes or open wounds. In case severe neighborhooderythema, oedema,
of
blistering or crusting,
less regularly or discontinue.
use
Avoid medicated or drying soaps, abrasive soaps and
common washing and cruel
cleansers,
scrubbing. Avoid use of
preparationswith excessiveconcentrations of alcohol, menthol,
topical
spices or lime. Oral: Children, hepatic or renal
impairment.
Reduce dose if intractable headache occurs.
quickly if LFT exceed 5instancesupper
Discontinue
restriction of normal. Monitorintently for leukocytosis orrespiratory compromise. Monitor
haematologic profile, coagulation parameters, LFT,
serum
triglyceride and ldl cholesterol
concentrations regularly.
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