Синтез (+)-aplykurodinone-1
SiPhonota geographica
Ретросинтетический анализ
Синтез
Ireland-claisen rearrangement
Dess-martin oxidation
Mitsunobu esterefication
1.21M
Category: chemistrychemistry
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Синтез (+)-aplykurodinone-1

1. Синтез (+)-aplykurodinone-1

СИНТЕЗ (+)-APLYKURODINONE-1
Вера Дорохова
ВХК РАН, А-41

2. SiPhonota geographica

SIPHONOTA GEOGRAPHICA

3. Ретросинтетический анализ

РЕТРОСИНТЕТИЧЕСКИЙ АНАЛИЗ

4. Синтез

СИНТЕЗ

5. Ireland-claisen rearrangement

IRELAND-CLAISEN REARRANGEMENT

6. Dess-martin oxidation

DESS-MARTIN OXIDATION

7.

8.

9.

10.

11.

12.

13. Mitsunobu esterefication

MITSUNOBU ESTEREFICATION

14.

11 steps
19% overall yield
Full stereochemical control
No protecting groups
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